Table 1.
Local Maxima for Contrasts Between Block A and B in 13 Healthy Controls and 14 1st Episode Bipolar Patients.
| Analysis Condition Region |
Number of Voxels |
x | y | z | SPM {t} |
|---|---|---|---|---|---|
| Early vs Late Block Comparisons | |||||
| Control: A > B | |||||
| No Active Voxels | -- | -- | -- | -- | -- |
| Control: B > A | |||||
| L Inferior Orbital Frontal Gyrus | 182 | -22 | 14 | -18 | 6.18 |
| L Caudate | 146 | -10 | -2 | 22 | 6.12 |
| L Inferior Orbital Frontal Gyrus | 86 | -34 | 42 | -4 | 6.04 |
| L Posterior Cingulate Gyrus | 115 | -4 | -30 | 24 | 5.65 |
| R Pallidum | 122 | 16 | -4 | -4 | 5.00 |
| R Parahippocampal Gyrus | 65 | 16 | -6 | -30 | 4.79 |
| R Superior Orbital Frontal Gyrus | 29 | 20 | 42 | -12 | 4.71 |
| Bipolar: A > B | |||||
| No Active Voxels | -- | -- | -- | -- | -- |
| Bipolar: B > A | |||||
| R Hippocampus | 579 | 40 | -18 | -8 | 9.93* |
| L Cerebellum | 240 | -14 | -62 | -24 | 7.17* |
| L Postcentral Gyrus | 208 | -52 | -8 | 22 | 6.69* |
| L Cerebellum | 42 | -8 | -46 | -6 | 6.56* |
| L Superior Parietal Lobe | 170 | -14 | -64 | 44 | 6.06* |
| R Middle Frontal Gyrus | 81 | 34 | 28 | 46 | 5.97* |
| R Precu neus | 211 | 20 | -52 | 18 | 5.62* |
| L Parahippocampal Gyrus | 36 | -18 | -30 | -18 | 5.53* |
| L Fusiform Gyrus | 36 | -40 | -8 | -22 | 5.31* |
| L Hippocampus | 186 | -34 | -36 | -6 | 5.29* |
| R Insula | 34 | 36 | 32 | 8 | 5.22 |
| R Cerebellum | 147 | 10 | -60 | -18 | 5.12 |
| L Calcarine Cortex | 28 | -28 | -66 | 4 | 5.07 |
| L Middle Occipital Gyrus | 85 | -28 | -88 | 14 | 5.05 |
| R Precuneus | 40 | 14 | -58 | 44 | 4.87 |
| L Anterior Cingulate Gyrus | 22 | -14 | 22 | 22 | 4.26 |
| Diagnostic Group Comparisons | |||||
| Block A: Bipolar > Control | |||||
| No Active Voxels | -- | -- | -- | -- | -- |
| Block A: Control > Bipolar | |||||
| L Calcarine Cortex | 53 | -6 | -70 | 20 | 3.81 |
| Bloc k B: Bipolar > Control | |||||
| R Superior Temporal Pole | 34 | 54 | 14 | -18 | 3.87 |
| Block B: Control > Bipolar | |||||
| L Putamen | 693 | -16 | 12 | -4 | 4.82 |
| L Caudate | 242 | -20 | -6 | 22 | 4.60 |
| L Anterior Cingulate Gyrus | 106 | -8 | 34 | 12 | 4.35 |
| R Middle Frontal Gyrus | 40 | 42 | 24 | 36 | 4.33 |
| R Superior Temporal Pole | 133 | 34 | 14 | -32 | 4.21 |
| R Inferior Orbital Frontal Gyrus | 21 | 26 | 28 | -6 | 3.86 |
| L Medial Orbital Frontal Gyrus | 25 | -12 | 48 | -6 | 3.76 |
Note. L = left hemisphere; R = right hemisphere. Atlas coordinates are from the MNI standard atlas, such that x reflects the distance (mm) to the right or left of midline, y reflects the distance anterior or posterior to the anterior commissure, and z reflects the distance superior or inferior to the horizontal plane through the AC-PC line. All activated voxels are significant at p < .001 (uncorrected), with a spatial extent of 20 contiguous voxels.
*
Survives False Discovery Rate (FDR) correction for whole brain volume at p < .05, with a spatial extent of at least 20 contiguous voxels.