Figure 4.

Axons in the ascending dOT are missorted at P8 in BMP and Noggin transgenics. A, B, Axons originating from ventral or dorsal retina in WT mice travel along the medial (M) or lateral (L) edges of the optic tract. C, D, In the Noggin-transgenic mice, axons from both ventral and dorsal retina lose their confinement in the dOT, although the disturbance of the dorsal axons is more severe. E, F, In BMP transgenic mice, the ventrally originating axons lose their restriction to medial dOT, whereas those from dorsal retina remain on the lateral side. G, Summary quantification of the position of the center of mass of fluorescent label across the medial-lateral width of the dOT (B, red bar) in WT, BMP-transgenic, and Noggin-transgenic mice for dorsal (blue) and ventral (red) retinal injections. In BMP-transgenic mice, only injections from ventral retinal show an inappropriate distribution in the dOT, whereas in Noggin transgenics, dorsal RGC axons are the most inappropriately distributed (*p < 0.01). Error bars indicate SEM.