Figure 7.

The LGN in BMP-transgenic mice contains axons that are mistargeted in a manner similar to that seen in the SC. A, B, In P8 BMP-transgenic mice, ventral axons often form ectopic spots (ES) lateral to the normal target zone (TZ). C, D, The dorsal and lateral subdivisions of the LGN each contain a retinotopic representation of the retina that is formed by the retinal axons as they pass through these structures on their way to the SC, making topographic appropriate synaptic connections via axon collaterals. In the BMP-transgenic mice, the disturbance of topography in the projection from ventral retina seen in the SC (A, B) is frequently accompanied by similar disruptions of retinotopy in the LGN (C, D). Scale bars: A, B, 500 μm; C, D, 250 μm.