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. 2009 Mar 13;84(3):307–315. doi: 10.1016/j.ajhg.2009.01.021

Figure 3.

Figure 3

Basal Activity of TRPV4 Wild-Type and TRPV4 Mutants

(A–D) Basal currents through wild-type TRPV4 (A), D333G (B), R594H (C), and A716S (D) transfected HEK cells in response to a voltage step protocol (40 mV steps from −80 mV to +200 mV).

(E) Average basal inward and outward currents at −150 and +150 mV in wild-type TRPV4 (n = 8), D333G (n = 12), R594H (n = 16) and A716S (n = 9) expressing HEK cells. ∗ indicates significant differences when compared with cells expressing wild-type TRPV4 (one-sided Student's t test, p < 0.05). Error bars represent means ± SE (standard error).