Table 2.

Results from Fine Mapping

SNP	Positiona	Gene	p Value (DG)b	p Value (RS1)c	p Value (RS2)d	Homogeneity Teste	p Value Common Genotype Effecte	OR [95% CI]e
chr7q22.1
rs2283029	28581795	RELN	0.009	0.695
rs17290575	28585197	RELN	0.374	0.021
rs262341	28602125	RELN	0.003	0.091
rs2299383	28602422	RELN	0.026	0.026	0.216	0.583	0.001	0.824 [0.732–0.928]
rs262355	28609691	RELN	0.015	0.536
rs17133096	28621061	RELN	0.566	0.023
rs11761011	28623116	RELN	0.007	0.745
rs39335f	28637145	RELN	0.017	0.022	0.143	0.561	5.39 × 10−4	0.741 [0.625–0.879]
rs39346	28649844	RELN	2.87 × 10−4	0.768
rs39347	28650074	RELN	0.019	0.779
rs39350	28650843	RELN	0.001	0.024	8.65 × 10−4	0.611	3.40 × 10−7	1.367 [1.212–1.543]
rs39374	28660243	RELN	2.04 × 10−5	0.048	2.13 × 10−5	0.160	1.55 × 10−9	1.441 [1.279–1.624]
rs12536007	28665264	RELN	0.219	0.049
rs39395f	28673305	RELN	2.00 × 10−4	0.011	7.23 × 10−6	0.399	6.23 × 10−10	0.685 [0.607–0.773]
rs39399	28673568	RELN	1.66 × 10−5	0.077
rs13223714	28673996	RELN	0.011	0.315
rs1510858	28676484	RELN	0.708	0.034
rs39401	28678969	RELN	2.50 × 10−4	0.204
rs7791481	28688422	RELN	0.010	0.037	0.052	0.746	1.62 × 10−4	1.394 [1.171–1.658]
rs2237641	28703347	RELN	0.221	0.045
rs3914129	28710441	RELN	0.017	0.302
rs3914132g	28710945	RELN	1.00 × 10−4	0.003	0.003	0.486	1.69 × 10−8	1.540 [1.323–1.793]
rs802786	28729984	RELN	0.016	0.061
chr11q13.1
rs670358g	9897474	CDC42BPG	0.028	0.022	0.005	0.968	2.38 × 10−5	0.658 [0.541–0.801]
rs494252	9905797	CDC42BPG	0.034	0.016	0.110	0.781	4.27 × 10−4	1.394 [1.157–1.679]
rs627497	9944958	EHD1	0.010	0.015	0.184	0.406	3.82 × 10−4	1.355 [1.145–1.604]
rs7949144	9964194		0.031	0.223
rs616322	9996670		0.001	0.017	0.065	0.409	2.20 × 10−5	1.458 [1.223–1.739]

SNPs significant in the discovery group and/or replication set 1 are listed. The most significant signal in each region is shown in bold

^aThe following nucleotide reference sequences were used: for chr11, NT_033903.7; for chr7, NT_007933.14.

^bp value in the discovery group.

^cp value in replication set 1.

^dp value in replication set 2.

^eCombined data of all populations (discovery group, first and second replication set).

^fOriginally captured as an MMP, but also genotyped after very significant predictions.

^gOriginally identified SNP by the whole-genome association study.