Table 6.

Summary of Association Results in GWAS and Replication Studies

SNP	US White GWAS Sample p Value	US White Family Sample p Value	Framingham Sample (White) p Value	Chinese HF Sample p Value	Chinese BMD Sample p Value	Tobago BMD Sample (African) p Value
ADAMTS18rs16945612	Hip BMD/female sample:5.75 × 10−7 (allele)4.61 × 10−4 (haplotype)	Hip BMD:1.6 × 10−2Spine BMD:3.5 × 10−3	Hip BMD: 6 × 10−3	Hip fracture: 1.9 × 10−2	Hip BMD:9 × 10−3 Spine BMD: 1 × 10−2	Hip BMD: 1.7 × 10−1 Trochanter BMD: 3.2 × 10−2
ADAMTS18rs11859065	Hip BMD/female sample:1.28 × 10−6 (allele)4.91 × 10−4 (haplotype)	Hip BMD:1.65 × 10−2 Spine BMD: 3.5 × 10−3	Hip BMD: 5.5 × 10−3	Hip fracture: 1.9 × 10−2	Hip BMD:9 × 10−3 Spine BMD: 1 × 10−2	NAa
ADAMTS18rs11864477	Hip BMD/female sample:4.17 × 10−7 (allele)2.90 × 10−5 (haplotype)	Hip BMD:1.65 × 10−2 Spine BMD: 3.5 × 10−3	Hip BMD: 6.5 × 10−3	Hip fracture: 1.9 × 10−2	Hip BMD:9 × 10−3 Spine BMD: 1 × 10−2	NAa
ADAMTS18rs11860781	Hip BMD/female sample:2.03 × 10−6 (allele)5.78 × 10−4 (haplotype)	Hip BMD: 1 × 10−2	Hip BMD: 1.0 × 10−2	Hip fracture: 1.7 × 10−1	Hip BMD: 1 × 10−1	NAa
TGFBR3rs17131547	Spine BMD/total sample:3.91 × 10−4 (allele)3.47 × 10−8 (haplotype)	Spine BMD: 1 × 10−2	Spine BMD: 3 × 10−2	NAb	NAb	Spine BMD: 6.7 × 10−3 Total body BMD: 3.1 × 10−2
						Hip BMD: 1.1 × 10−3
						Femoral Neck BMD: 5.4 × 10−3
						Intertrochanter BMD: 4.93 × 10−4
						Trochanter BMD: 1.3 × 10−2
						Ward's triangle BMD: 2.82 × 10−4

^ars11859065, rs11864477 and rs11860781 was not genotyped in Tobago sample considering the redundancy in genotyping since they are all in strong LD with rs16945612 in the HapMap African sample.

^brs17131547 was monomorphic in Chinese.