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. 2009 Mar 13;84(3):388–398. doi: 10.1016/j.ajhg.2009.01.025

Table 8.

Results of Meta-Analyses Using the Weighted z Score-Based Approach

SNP p Value of All White BMD Samples Combineda p Value of All BMD Samples combinedb
ADAMTS18:rs16945612 Hip BMD:2.84 × 10−7 Hip BMD:2.13 × 10−8
ADAMTS18:rs11859065 Hip BMD:3.57 × 10−7 Hip BMD:3.13 × 10−8
ADAMTS18:rs11864477 Hip BMD:2.75 × 10−7 Hip BMD:2.48 × 10−8
ADAMTS18:rs11860781 Hip BMD:5.37 × 10−7 Hip BMD:1.19 × 10−6
TGFBR3:rs17131547 Spine BMD:2.56 × 10−5 Spine BMD:1.49 × 10−6

The z score is weighted by the square root of the sample size of each combining sample.

a

Including white U.S. GWAS, white U.S. family and Framingham samples (whites). N = 5925.

b

Including white U.S. GWAS, white U.S. family, Framingham sample, Chinese BMD and Tobago BMD samples for ADAMTS18 SNPs - rs16945612; including white U.S. GWAS, white U.S. family, Framingham sample, and Chinese BMD sample for the other three ADAMTS18 SNPs that were not genotyped in Tobago sample; while including white U.S. GWAS, white U.S. family, Framingham sample, and Tobago BMD sample for TGFBR3 - rs17131547, which is monomorphic in Chinese. N = 9,828 for ADAMTS18 SNPs - rs16945612; N = 8,920 for other ADAMTS18 SNPs; N = 6833 for the TGFBR3 SNP.