Figure 3.
Cluster 2 C6orf29 Network
Diagrammed in the figure are the predicted transcript relationships given from our analysis using NEO25 to impart directionality on the transcript-transcript correlations that we predicted from HQCUT22 for the transcripts in cluster 2. For clarity, only transcripts that had correlations with SNP genotype and an interaction with C6orf29 are listed (25% of cluster 2). In the figure, SNP-transcript relationships are given by dashed arrows and transcript-transcript relationships by solid arrows. Transcripts are indicated by circles, gray circles indicating transcripts where there was a significant interaction with diagnosis in the eQTL analysis and white circles indicating no significant interaction term. Bidirectional arrows indicate a feedback loop between the two transcripts analyzed as predicted by NEO analysis. Bidirectional arrows divided by black circles indicate that NEO predicted an unmapped hidden confounder in the analysis of the relationship between the two transcripts.