Figure 2.

Homozygosity by Descent Mapping

(A) Homozygosity by descent mapping in family R01-314. All intervals of homozygosity shared among the four affected family members of family R01-314 are plotted across the genome. Chromosomal position is indicated on the x axis, and length of the homozygous interval is plotted on the y axis such that height of the filled-in graphic indicates the length of the measured homozygous intervals in centimorgans. Physical distances: chromosome 1 (rs11209979-rs4656100; 71,153,296-85,028,578bp), chromosome 11 (rs 10501715-rs1029278; 86,043.913-119,363,025bp), and chromosome 16 (rs12924823-rs12928078; 10,726,309-24,280,658bp).