Table 2.

SNPs Associated with β-carotene at p < 5 × 10⁻⁷ in the InCHIANTI GWAS and Follow-up Results in the WHAS and the ATBC Study

Study	SNP	Allelesa	Chromosome	MAF	N	Effect (95% Confidence Intervals)a	Standard Error	p Value
inCHIANTI	rs6513787	C/A	20	0.08	1190	−0.222 (−0.306, −0.137)	0.043	3.6 × 10−7
inCHIANTI	rs6420424	G/A	16	0.34	1191	0.152 (0.103, 0.201)	0.025	1.9 × 10−9
inCHIANTI	rs8044334	T/G	16	0.24	1189	0.161 (0.106, 0.216)	0.028	1.3 × 10−8
inCHIANTI	rs11645428	G/A	16	0.47	1190	−0.118 (−0.165, −0.072)	0.024	8.3 × 10−7
inCHIANTI	rs6564851	T/G	16	0.36	1171	0.160 (0.112, 0.208)	0.024	9.7 × 10−11
WHASc	rs6513787	C/A	20	0.05	576	−0.100 (−0.307, 0.107)	0.106	0.34
WHASc	rs6420424	G/A	16	0.49	602	0.165 (0.082, 0.248)	0.042	1.0 × 10−4
WHASc	rs8044334	T/G	16	0.36	597	0.169 (0.084, 0.255)	0.044	1.1 × 10−4
WHASc	rs11645428	G/A	16	0.33	599	−0.196 (−0.279, −0.113)	0.042	3.7 × 10−6
WHASc	rs6564851	T/G	16	0.48	602	0.199 (0.116, 0.282)	0.042	2.6 × 10−6
ATBC	rs6513787	C/A	20	0.04	2126	−0.03 (−0.13, 0.07)	0.05	0.13
ATBC	rs6420424b	G/A	16	N/A	N/A	N/A	N/A	N/A
ATBC	rs8044334	T/G	16	0.35	2129	0.07 (0.034, 0.114)	0.02	0.0003
ATBC	rs11645428	G/A	16	0.28	2129	−0.12 (−0.160, 0.075)	0.022	7.4 × 10−8
ATBC	rs6564851	T/G	16	0.39	2108	0.13 (0.092, 0.171)	0.020	1.1 × 10−10
Meta-analysis	rs6513787	C/A	20		3892	−0.136 (−0.197, −0.075)	0.031	1.4 × 10−5
Meta-analysis	rs6420424	G/A	16		1793	0.155 (0.11, 0.198)	0.022	6.5 × 10−13
Meta-analysis	rs8044334	T/G	16		3915	0.109 (0.079, 0.139)	0.015	9.3 × 10−13
Meta-analysis	rs11645428	G/A	16		3918	−0.129 (−0.159, −0.099)	0.015	1.5 × 10−17
Meta-analysis	rs6564851	T/G	16		3881	0.149 (0.120, 0.177)	0.015	1.6 × 10−24

N/A = not available, MAF = minor allele frequency.

^aEffect direction refers to second allele.

^brs6420424 failed genotyping in the ATBC study.

^cMeta-analysis results of WHAS I and II are given.