Table 4.

SNPs Associated with α-Tocopherol at p < 5 × 10⁻⁷ in the InCHIANTI GWAS and Follow-up Results in the WHAS and ATBC Studies

Study	SNP	Alleles	CHR	MAF	N	Effect	Standard Error	p Value
inCHIANTI	rs12272004	C/A	11	0.05	1170	0.11(0.066, 0.15)	0.022	3.9 × 10−7
inCHIANTI	rs2903269	C/T	4	0.18	1180	0.062(0.039, 0.085)	0.012	1.7 × 10−7
WHAS	rs12272004	C/A	11	0.06	588	0.121(0.048, 0.194)	0.037	0.001
WHAS	rs2903269	C/T	4	0.19	601	0.04(−0.015, 0.095)	0.028	0.160
ATBC	rs12272004	C/A	11	0.07	2133	0.047(0.017, 0.077)	0.015	0.0019
ATBC	rs2903269	C/T	4	0.30	2130	0.009(−0.014, 0.020)	0.009	0.76
Meta-analysis	rs12272004	C/A	11		3891	0.072(0.049, 0.095)	0.012	7.8 × 10−10
Meta-analysis	rs2903269	C/T	4		3911	0.034(−0.01, 0.08)	0.016	0.14a

^aRandom-effects meta-analysis was used because of highly significant heterogeneity.