Table 5.
Effects of Known Lipid SNPs on α-Tocopherol Levels
| SNP | Nearest Gene(s) | Allele | Allele Frequency | Genotyped Proxy SNP Used (r2) | Effect (95% Confidence Intervals) | p Value |
|---|---|---|---|---|---|---|
| HDL-Lowering Variants | ||||||
| rs4149268 | ABCA1 | C | 0.27 | −0.32 (−0.96 to 0.31) | 0.32 | |
| rs1800775 | CETP | C | 0.43 | −0.86 (−1.49 to −0.23) | 0.007 | |
| rs2144300 | GALNT2 | C | 0.42 | rs10779835 (0.97) | −0.28 (−0.89 to 0.33) | 0.37 |
| rs1800588 | LIPC | C | 0.74 | −1.08 (−1.82 to −0.34) | 0.004 | |
| rs2156552 | LIPG | A | 0.80 | rs4939883 (0.95) | −0.97 (−1.88, −0.057) | 0.04 |
| rs328 | LPL | C | 0.88 | −0.55 (−1.41 to 0.31) | 0.21 | |
| rs2238104 | MVK-MMAB | C | 0.56 | −0.21 (−0.83 to 0.42) | 0.52 | |
| LDL-Raising Variants | ||||||
| rs693 | APOB | A | 0.49 | 0.72 (0.11 to 1.33) | 0.021 | |
| APOE | ɛ4 | 0.09 | 0.68 (−0.58 to 1.93) | 0.29 | ||
| rs646776 | CELSR2-PSRC1-SORT1 | T | 0.71 | 0.44 (−0.34 to 1.22) | 0.27 | |
| rs12654264 | HMGCR | T | 0.42 | rs6896136 (0.87) | 0.31 (−0.30 to 0.92) | 0.32 |
| rs6511720 | LDLR | G | 0.10 | −1.23 (−2.14 to −0.32) | 0.008 | |
| rs11206510 | PCSK9 | T | 0.85 | 0.49 (−0.28 to 1.27) | 0.21 | |
| Triglyceride-Raising Variants | ||||||
| rs1748195 | ANGPTL3 | C | 0.68 | rs1167998 (1.00) | −0.69 (−1.36 to −0.028) | 0.041 |
| rs662799 | APOA1-C3-A4-A5 | G | 0.02 | 2.38 (0.05, 0.019) | 7.3 × 10−7 | |
| rs3135506 | APOA1-C3-A4-A5 | G | 0.06 | rs12272004 (0.88) | 2.94 (1.63 to 4.26) | 1.2 × 10−5 |
| rs693 | APOB | A | 0.49 | 0.72 (0.11 to 1.33) | 0.021 | |
| rs2144300 | GALNT2 | C | 0.42 | rs10779835 (0.97) | 0.28 (−0.33 to 0.89) | 0.37 |
| rs780094 | GCKR | T | 0.38 | −0.28 (−0.89 to 0.34) | 0.38 | |
| rs328 | LPL | C | 0.88 | −0.55 (−1.41 to 0.31) | 0.21 | |
| rs17145738 | MLXIPL | C | 0.88 | rs2240466 (1.00) | 0.04 (−1.13 to 1.22) | 0.94 |
| rs17321515 | TRIB1 | A | 0.60 | rs6982636 (1.00) | −0.32 (−0.95 to 0.30) | 0.31 |