Table 2.
Maximum LOD Scores in the Three Candidate Regions
|
From |
To |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chromosome | Region | SNP | Mb | SNP | Mb | Families | NPL (Max) | p Value | HLOD (Max) |
| 3 | q25.33-q26.2 | rs1472578 | 160.29 | rs1920122 | 170.98 | 6(6) | 2.46 | 0.007 | 3.01 |
| 6 | q24.3-q25.1 | rs612928 | 144.64 | rs1407491 | 153.03 | 7(5) | 2.65 | 0.004 | 2.26 |
| 21 | q22.13 | rs1012959 | 36.98 | rs2836301 | 38.59 | 5(5) | 4.37 | 0.00001 | 3.55 |
Nonparametric (NPL) and parametric (HLOD) LOD scores obtained from the whole set of 41 families for the three candidate regions. The number of putative linked families is shown before and after fine-mapping strategy. In bold and italics is shown the significant HLOD value for chromosome 21.