Table 3.
Clinical Features of the Linked Families for Each Candidate Region
| Chromosome | Region | Family ID | Breast Cases | Bilateral Cases | Mean Age | Related Cancers |
|---|---|---|---|---|---|---|
| 3 | 3q25 | 3 | 4 | 1 | 47.4 | |
| 5 | 7 | 1 | 50.3 | lymphoma | ||
| 10 | 8 | 1 | 52.8 | leukemia | ||
| 21 | 3 | 0 | 50.3 | colon | ||
| 27 | 4 | 0 | 47.5 | gastric | ||
|
24 |
6 |
1 |
59.5 |
lymphoma |
||
| 6 | 6q24 | 2 | 4 | 0 | 38.2 | thyroid |
| 6 | 5 | 1 | 51.1 | bladder | ||
| 31 | 3 | 0 | 43.1 | CNS/CRCa | ||
| 33 | 5 | 0 | 50.8 | |||
| 35 |
4 |
0 |
49.2 |
|||
| 21 | 21q22 | 8 | 3 | 2 | 46.7 | colon |
| 9 | 4 | 0 | 40.7 | |||
| 18 | 4 | 1 | 46.1 | |||
| 41 | 4 | 0 | 51.5 | |||
| 24 | 6 | 1 | 59.5 | lymphoma |
Family 24 was confirmed as linked to both chromosome 3 and 21 candidate regions.
a
CNS, central nervous system tumor; CRC, colorectal cancer.