Table 4.
Maximum HLOD Scores in the Three Candidate Regions via SNP and STR Markers
|
From |
To |
||||||
|---|---|---|---|---|---|---|---|
| Chromosome | Region | SNP | Mb | SNP | Mb | HLOD SNPs | HLOD SNPs + FM STRs |
| 3 | q25.33-q26.2 | rs1472578 | 160.29 | rs905129 | 172.43 | 5.33 | 5.46 |
| 6 | q24.3-q25.1 | rs612928 | 144.64 | rs1407491 | 153.03 | 4.93/3.33 | 3.40/3.39 |
| 21 | q22.11-q22.13 | rs762173 | 32.75 | rs2836301 | 38.59 | 3.57 | 3.68 |
Parametric (HLOD) LOD scores obtained from the candidates families for the three candidate regions before and after fine-mapping. In chromosome 6, HLOD score is shown for the seven initial putative linked families and the five final putative linked families. The three regions were confirmed after fine-mapping.