Table 2.

Haplogroup Distribution of Affected and Unaffected Individuals in 182 Families with the Primary Mutation m.11778G→A

Sex and Haplogroup	No. of Individuals with G11778A
	Affected	Unaffected
Male
M7b1′2	41	27
M7c	25	42
M8a	15	39
C	20	9
M10	30	33
D4	91	129
D5	37	34
A	24	16
B4	44	57
B5	21	32
G	41	26
Y	14	20
F	7	5
Other	26	35
Total	436	504
Female
M7b1′2	15	53
M7c	9	46
M8a	7	51
C	3	14
M10	10	40
D4	43	169
D5	23	67
A	7	28
B4	20	76
B5	10	52
G	21	51
Y	1	25
F	3	12
Other	11	52
Total	183	736

The previously reported Chinese families with LHON and m.11778G→A^{25,26,28–32} were included. For detailed information, refer to Tables S1 and S2.