Table 3.

Effect of Gender and mtDNA Haplogroups on Phenotypic Manifestation of the Primary Mutation m.11778G→A

Variable	All 182 Families			140 Familiesa
	p Value	Odds Ratio	95% CI	p Value	Odds Ratio	95% CI
Sex	2.613 × 10−32	3.479	2.830–4.277	5.576 × 10−27	3.324	2.671–4.138
M7b1′2	0.032	1.503	1.035–2.183	0.015	1.631	1.100–2.416
M7c	0.101	0.702	0.460–1.071	0.123	0.706	0.454–1.099
M8a	0.002	0.460	0.282–0.751	0.001	0.391	0.224–0.682
C	0.050	1.845	1.000–3.404	0.154	1.655	0.828–3.308
M10	0.861	1.038	0.685–1.571	0.451	1.173	0.775–1.778
D4	0.213	0.858	0.675–1.092	0.151	0.827	0.638–1.071
D5	0.092	1.353	0.952–1.923	0.076	1.394	0.965–2.013
A	0.157	1.426	0.872–2.331	0.154	1.467	0.867–2.481
B4	0.744	0.947	0.682–1.314	0.911	0.981	0.697–1.381
B5	0.204	0.752	0.484–1.167	0.165	0.714	0.443–1.149
G	0.001	1.827	1.266–2.637	0.003	1.825	1.230–2.709
Y	0.091	0.590	0.320–1.088	0.097	0.580	0.305–1.104
Fb	0.530	1.302	0.571–2.966	–	–	–
Other	0.429	0.847	0.560–1.280	0.705	0.928	0.629–1.368

Statistical testing was performed on the basis of the original data in Table S2. The visual failure was regarded as the dependent variable in the binary logistic-regression model. The haplogroups (present in at least four families) were separately introduced into the regression equation with the independent variable sex and the dependent variable visual failure.

^a42 small pedigrees were excluded.

^bWhen the small pedigrees were not considered, haplogroup F was excluded because of the small number of families.