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Results of regression analysis to determine the contributions of covariates to variability in trough total plasma concentrations of (RS)-, (R)- and (S)-methadone in methadone maintenance therapy patients
| Covariate | (RS)- | (R)- | (S)- |
|---|---|---|---|
| Dose of methadone | 29% | 29% | 25% |
| Duration of addiction | 25% | 24% | 20% |
| CYP 3A activity | 7% | 8% | 8% |
| Continued abuse of morphine | 7% | – | 8% |
| Total contribution (%) | 68% | 61% | 61% |
| P-value | <0.001 | <0.001 | <0.001 |
