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Results of regression analysis to determine the contributions of CYP3A activity and use of abused morphine to the oral clearance of (RS)-, (R)- and (S)-methadone
| (RS-) | (R-) | (S-) | ||
|---|---|---|---|---|
| Total | Unbound | Total | Unbound | |
| CYP 3A activity | 15% | 22% | 23% | 16% |
| Abused morphine | – | 14% | – | 10% |
| Total | 15% | 36% | 23% | 26% |
| P-value | 0.033 | 0.001 | 0.005 | 0.009 |
