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Regression equations describing relationships between oral clearance of methadone and its enantiomers and significant covariates
| CL/F of total (RS)-methadone = 4.53 + (0.04 × CYP3AA) |
| CL/F of unbound (R)-methadone = −141.3 + (6.3 × CYP3AA) + (86.5 × AM) |
| CL/F of total (S)-methadone = 3.8 + (0.05 × CYP3AA) |
| CL/F of unbound (S)-methadone = 136.6 + (1.7 × AM) |
CYP3AA, CYP3A activity [as measured by oral midazolam clearance (l h−1)]; AM, abuse of morphine (positive = 1, negative = 0).
