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Usual interstitial pneumonia (UIP). UIP is characterised by zones of normal lung tissue adjacent to zones of advanced architectural remodelling (temporal heterogeneity). (A) Early in the disease process, an interrupted “rind” of subpleural fibrosis is visible. (B) A more advanced stage shows more extensive perilobular fibrosis with relative centrilobular sparing, producing ring-like scarring at scanning magnification. (A,B) H&E stain, 1× original magnification.
