Fig. 1.
Effects of a neurotoxic METH regimen on striatal DA levels in wild-type and CX3CR1 knockout (KO) mice. Female (a) and male (b) mice (n = 5-8 per group) were treated with METH (4 × 5 mg/kg). Striatal DA levels were determined 2-day, 7-day, and 14-day post-METH. Results are presented as mean % of saline-treated controls ± SEM. DA levels in striatum of untreated mice were 17.5 ng/mg tissue (wet weight). Significant differences were determined via oneway ANOVA followed by Tukey's multiple comparison test, and are indicated as follows: *p < 0.001 relative to control (Con).