Table 2.
Linear regression model of uric acid and inflammatory parameters, and their mean levels across the quintiles
| Serum uric acid (mg/dL) |
Serum uric acid (quintiles)a |
||||||
|---|---|---|---|---|---|---|---|
| Inflammatory parameters | β ± SEb | P-valueb | 1 (n = 196) | 2 (n = 190) | 3 (n = 205) | 4 (n = 185) | 5 (n = 181) |
| 1.4–4.0 mg/dL | 4.1–4.7 mg/dL | 4.8–5.3 mg/dL | 5.4–6.1 mg/dL | 6.2–11.6 mg/dL | |||
| White blood cells (K/μL) | 0.18 ± 0.04 | <0.0001 | 5.8 (5.5–6.2) | 6.0 (5.7–6.3) | 6.1 (5.7–6.4) | 6.2 (5.9–6.5) | 6.5 (6.4–6.6) |
| Neutrophilsc (K/μL) | 0.04 ± 0.01 | <0.001 | 3.3 (3.1–3.6) | 3.4 (3.2–3.7) | 3.5 (3.3–3.8) | 3.7 (3.4–3.9) | 3.8 (3.7–3.9) |
| Lymphocytesc (K/μL) | 0.02 ± 0.01 | 0.069 | 1.8 (1.6–1.9) | 1.7 (1.6–1.9) | 1.7 (1.6–1.8) | 1.8 (1.6–1.9) | 1.9 (1.8–2.0) |
| CRPc (μg/mL) | 0.14 ± 0.03 | <0.0001 | 2.2 (1.8–2.8) | 2.5 (2.0–3.2) | 2.6 (2.1–3.2) | 3.0 (2.5–3.8) | 3.5 (3.4–3.6) |
| ESRc (mm/h) | 0.03 ± 0.02 | 0.087 | 14.8 (12.6–17.4) | 15.1 (12.9–17.7) | 13.6 (11.7–15.9) | 16.8 (14.4–19.7) | 16 (13.6–18.7) |
| IL-1c (pg/mL) | 0.10 ± 0.08 | 0.185 | 1.0 (0.5–2.0) | 1.1 (0.5–2.1) | 1.0 (0.6–2.0) | 1.6 (0.8–3.1) | 1.0 (0.5–2.0) |
| IL-1rac (pg/mL) | 0.11 ± 0.01 | <0.0001 | 112 (100–126) | 122 (108–137) | 131 (117–147) | 143 (127–160) | 162 (144–182) |
| IL-6c (pg/mL) | 0.08 ± 0.02 | 0.0002 | 1.2 (1.0–1.4) | 1.4 (1.2–1.6) | 1.4 (1.2–1.7) | 1.5 (1.2–1.8) | 1.7 (1.5–1.9) |
| sIL-6rc (ng/ml) | 0.04 ± 0.01 | 0.0021 | 86.0 (77.1–96.0) | 87.0 (78.0–96.7) | 90.6 (81.6–100.5) | 92.0 (82.4–02.0) | 102.0 (90.8–115.0) |
| TNF-αc (pg/mL) | 0.1 ± 0.01 | <0.0001 | 2.2 (1.3–2.7) | 2.3 (1.9–2.6) | 2.3 (2.0–2.7) | 2.7 (2.4–3.2) | 2.8 (2.7–3.2) |
| IL-8c (pg/mL) | 0.03 ± 0.05 | 0.574 | 5.4 (3.5–8.2) | 4.6 (3.0–7.0) | 6.2 (4.2–9.2) | 5.4 (3.6–8.1) | 5.0 (4.5–5.7) |
| IL-10c (pg/mL) | 0.11 ± 0.04 | 0.007 | 0.9 (0.6–1.3) | 0.8 (0.6–1.1) | 1.1 (0.8–1.4) | 0.9 (0.7–1.3) | 1.1 (0.9–1.2) |
| IL-12c (pg/mL) | 0.10 ± 0.05 | 0.052 | 3.1 (2.0–4.9) | 3.0 (1.9–4.8) | 3.1 (2.1–4.7) | 3.8 (2.5–6.0) | 3.8 (3.4–4.3) |
| IL-18c (μg/mL) | 0.03 ± 0.01 | <0.0001 | 351 (332–382) | 355 (331–380) | 379 (354–404) | 411 (384–440) | 399 (355–449) |
a
Data are reported as mean ± 95% confidence intervals according to uric acid quintiles.
b
β Coefficients ± standard errors and P-test are from age- and sex-adjusted linear models using UA as a continuous independent variable.
c
Log-transformed values were then back-transformed for data presentation.