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. Author manuscript; available in PMC: 2009 Dec 25.
Published in final edited form as: J Med Chem. 2008 Dec 25;51(24):7788–7799. doi: 10.1021/jm800781a

Table 2.

Results of In Vitro Competition Binding Assays with Transfected Human Monoamine Transporters.

Ki (nM)a
 SERT selectivity
Compd hSERT hDAT hNET DAT/SERT NET/SERT
1 0.43 ± 0.01b 87.6 ± 10.2b 109.9 ± 6.3c ~204 ~256
2 0.33 ± 0.10b 35.5 ± 5.9b 101.3 ± 2.5b ~108 ~307
3 0.26 ± 0.03b 179.7 ± 17.8b 67.5 ± 5.6b ~691 ~260
4 0.33 ± 0.03b 118.7 ± 13.8b 30.2 ± 0.4b ~360 ~92
trans-1 15.2 ± 3.9b 274.0 ± 9.3b 1180 ± 426b ~18 ~78
a)

= Average value of n determinations ± SEM (each determination performed in triplicate).

b)

n = 2.

c)

n = 3.