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Negative regulation of PRR signaling. Signaling through PRRs is negatively regulated by endogenous and microbial proteins. Endogenous negative control of PRR signaling (molecules depicted in red) serves the purpose of mediating negative feedback on the inflammatory response, whereas microbial interference with PRRs (viral molecules shown in green) constitutes a means to evade the host antimicrobial response. See text for further details.
