TABLE 5.
Immunological methods for the diagnosis of cysticercosis in CSF samplesa
Target | Method | Material | Sensitivity (%) | Specificity (%) | Reference |
---|---|---|---|---|---|
Fractions, saline/SDS | ELISA | CSF | Tso-NaCl: 100 | Tso-NaCl: 100 | 12 |
Tcra-NaCl: 85 | Tcra-NaCl: 100 | ||||
Tso-SDS: 95 | Tso-SDS: 100 | ||||
Tcra-SDS: 87 | Tcra-SDS: 97 | ||||
Antigen | ELISA | CSF | 218 | ||
Anti-Tso | 81 | 82 | |||
Anti-Cra | 90 | 98 | |||
Anti-Cra, <30 kDa | 95 | 100 | |||
ES antigens | ELISA | CSF | 92 | 97 | 192 |
14- and 18-kDa antigens | ELISA | CSF | 100 | 100 | 217 |
14-kDa antigen | ELISA | CSF | 95 | 100 | 221 |
Peptides HP6-2 and Ts45W-1 | ELISA | CSF | 93 | 85 | 100 |
14 and 18-kDa antigen | ELISA | CSF and serum | 100 | 100 | 91 |
10-kDa antigen, recombinant | ELISA | CSF | 91 | NR | 162 |
Serum | 97 | 96 | |||
14-kDa antigen, recombinant | ELISA | CSF | 100 | 100 | 69 |
Serum | 97 | 100 | |||
Fractions: 47-52, 64-68 and | WB | CSF | 100 | NR | 11 |
70 kDa | Serum | 80 | NR | ||
Crude antigen (W) and VF, Tso and Tcra | ELISA | CSF | TsoW, 91; TcraW, 87; TsoVF, 91; TcraVF, 91 | TsoW, 94; TcraW, 94; TsoVF, 97; TcraVF, 97 | 274 |
Tso, Taenia solium; Tcra, Taenia crassiceps; NaCl, saline extract; SDS, sodium dodecyl sulfate extract; W, worm; VF, vesicular fluid; NR, not reported.