. Author manuscript; available in PMC: 2009 Apr 13.

Published in final edited form as: Cytokine Growth Factor Rev. 2005 Jul 5;16(6):637–658. doi: 10.1016/j.cytogfr.2005.05.008

Table 6.

N- linked and O-linked glycosylation of chemokine receptors

Receptor	Residues^a	Cell type	Ligand	Effect	Reference^b
CCR2B	N₁₄^c	HEK293^d	None	= Surface expression	[153]
CCR5	S₆^e (S₇^e)	HEK293^d; HeLa^d; MF^d; Cf2Th-CD4^d	None	= Surface expression	[132,133]
		Cf2Th-CD4^d	CCL3-4	+ Binding	[133]
			HIV-1; SIV	= HIVco	[133]
CXCR2	N₁₇^c; N₁₈₆^c; N₁₉₇^c	Neutrophils	None	+ Proteolytic protection	[152]
			CXCL7	= Granulation, endocytosis, recycling	[152]
CXCR4	N^c	HEK293T^d; HuTK⁻^d			[141,188]
	N₁₁; (N₁₇₆)	CCC^d; Mv-1-lu^d	None	+ Surface expression	[145]
			HIV-2	3 HIVco	[145]
		BSC-1^d	None	= Surface expression	[144]
		U373-MG-CD4⁺^d	R5 HIV-1	3 HIVco	[144]
			X4 HIV-1	= HIVco	[144]
		Cf2-Th^d + sCD4	None	= Surface expression	[146]
			X4 HIV-1	3 Binding; HIVco	[146]
			R5 HIV-1	3 Binding; HIVco	[146]
			CXCL12	+ Binding; [Ca]	[146]
D6	N₁₇	L1.2^d	Murine CCL3	= Binding	[156]
DARC	N₁₆	K562^d		= Surface expression	[155]
			CXCL8	= Binding	[155]

HIVco: HIV co-receptor activity; MF: primary rhesus macrophages; sCD4: in the presence of soluble CD4; Ca: calcium mobilization. The term inside the paranthesis indicates glycosylation site effectively used, but to lesser extent or with less biological consequences. [Ca] indicates calcium mobilization likely indirect effect, namely due to enhanced ligand binding.

Residues are O-linked or N-linked glycosylated on a specific Ser (S) or Asn (N) residue, respectively. Glycosylation can promote (+), inhibit (−) or not affect the specific effect mentioned.

References include only those in which glycosylation was really demonstrated.

Still unclear whether that particular potential glycosylation site was effectively glycosylated.

Cells were transfected with the corresponding chemokine receptor.

Glycans were sialylated.