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Representative example of MHC class II molecule-peptide formation. Binding of the MHC class II molecule to peptides is visualized using a Cy5 fluorochrome-conjugated anti-human HLA-DR antibody. CD4+ HIV T-cell epitopes, listed in the HIV Los Alamos database, form a complex with the DRB1*101 molecule. The peptide species share a potential MHC class II binding motive (FEPIPIHYC) (http://www.hiv.lanl.gov/content/immunology/index.html) (19, 46).
