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Histamine and oxidation potentiate Ca2+ signaling. [Ca2+]c was monitored in undifferentiated PC12 cells with fura-2. (A) Control K+ depolarization followed by application of 100 μM histamine and subsequent K+ depolarization. (B) [Ca2+]c responses to K+ depolarization before, during, and after combined application of 100 μM histamine and 0.03% H2O2. Representative results are from the series of four experiments.
