TABLE 1.
Similarity of DNA sequences of PPE gene family orthologues in the MAC
| MAC PPE locus name | M. tuberculosis orthologue | Locus name in:
|
Sub- lineage | % Identity between the following pairs by nucleotide sequence alignment of PPE gene orthologues:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M. avium subsp. paratuberculosis | M. avium subsp. hominissuis | M. avium subsp. avium | M. intracellulare | M. avium subsp. paratuberculosis-M. avium subsp. hominissuis | M. avium subsp. paratuberculosis- M. avium subsp. avium | M. avium subsp. paratuberculosis- M. intracellulare | M. avium subsp. hominissuis- M. avium subsp. avium | M. avium subsp. hominissuis-M. intracellulare | M. avium subsp. avium-M. intracellulare | |||
| MACPPE1 | PPE20 | MAP0123 | Mav_0118 | MaaPPE1 | MiPPE1 | II | 99.7 | 99.3 | 83.4 | 97.9 | 81.4 | 81.1 |
| MACPPE1 | PPE20 | MAP0124 | Mav_0118 | MaaPPE1 | MiPPE1 | (II)* | 98.3 | 95.5 | 74.7 | 97.9 | 81.4 | 81.1 |
| MACPPE2 | PPE69 | MAP0158 | Mav_0152 | MaaPPE2 | MiPPE2 | III | 99.2 | 99.3 | 76.7 | 100.0 | 80.3 | 76.5 |
| MACPPE3 | PPE65 | MAP0442 | Mav_0535 | MaaPPE3 | MiPPE3 | IV | 99.0 | 98.8 | 77.3 | 99.0 | 80.7 | 77.3 |
| MACPPE4 | Aa | Mav_0790c | I | |||||||||
| MACPPE5 | A | MAP0966c | MaaPPE5 | MiPPE5 | V | 98.6 | 83.0 | 82.8 | ||||
| MACPPE6 | PPE15 | MAP1003c | Mav_1179 | MaaPPE6 | MiPPE6 | IV | 99.4 | 99.6 | 84.4 | 99.5 | 84.7 | 84.5 |
| MACPPE7 | A | MAP2601 | Mav_1322c | MaaPPE7 | MiPPE7 | IV | 99.1 | 99.0 | 77.0 | 99.9 | 76.9 | 76.8 |
| MACPPE8 | A | MAP2600 | Mav_1324c | MaaPPE8 | MiPPE8 | IV | 99.3 | 99.3 | 80.3 | 100.0 | 79.7 | 79.7 |
| MACPPE9 | A | MAP2595 | Mav_1329c | MaaPPE9 | MiPPE9 | II | 99.0 | 99.1 | 82.6 | 100.0 | 81.3 | 82.4 |
| MACPPE10 | PPE18 | MAP2575c | Mav_1347 | MaaPPE10 | MiPPE10 | IV | 99.0 | 99.1 | 81.4 | 99.9 | 81.0 | 81.1 |
| MACPPE11 | A | Mav_1998 | MaaPPE11 | MiPPE11 | IV | 73.1 | 73.1 | 90.3 | ||||
| MACPPE12 | A | Mav_2006 | IV | |||||||||
| MACPPE13 | A | MAP2136c | Mav_2039 | MaaPPE13 | MiPPE13 | IV | 99.0 | 99.1 | 80.8 | 99.9 | 80.8 | 80.8 |
| MACPPE14 | A | MAP1813c | Mav_2429 | MaaPPE14 | MiPPE14 | II | 97.5 | 97.5 | 83.2 | 99.0 | 83.4 | 83.2 |
| MACPPE15 | A | NT03MA1810 | Mav_2514c | MaaPPE15 | II | 98.3 | 98.1 | 98.6 | ||||
| MACPPE16 | A | MAP1675 | Mav_2746c | MaaPPE16 | MiPPE16 | (IV)* | 100.0 | 98.8 | 89.2 | 100.0 | 76.7 | 89.6 |
| MACPPE16 | A | MAP1676 | Mav_2746c | MaaPPE16 | MiPPE16 | IV | 99.4 | 98.6 | 72.3 | 99.5 | 76.7 | 70.5 |
| MACPPE17 | PPE33 | MAP1522 | Mav_2905c | MaaPPE17 | MiPPE17 | IV | 98.9 | 98.6 | 86.0 | 98.9 | 85.3 | 85.3 |
| MACPPE18 | PPE29, PPE32 | MAP1521 | Mav_2906c | MaaPPE18 | MiPPE18 | IV | 98.9 | 99.0 | 88.4 | 99.4 | 88.7 | 89.0 |
| MACPPE19 | PPE30, PPE33 | MAP1519 | Mav_2909c | MaaPPE19 | MiPPE19 | IV | 99.2 | 99.4 | 87.5 | 99.2 | 87.8 | 87.5 |
| MACPPE20 | PPE32 | MAP1518 | Mav_2910c | MaaPPE20 | MiPPE20 | IV | 98.4 | 98.3 | 86.2 | 99.9 | 86.0 | 86.0 |
| MACPPE21 | PPE31 | MAP1516 | Mav_2913c | MaaPPE21 | IV | 98.6 | 98.6 | 100.0 | ||||
| MACPPE22 | PPE31 | MAP1515 | Mav_2914c | MaaPPE22 | IV | 98.2 | 98.1 | 99.9 | ||||
| MACPPE23 | PPE26 | MAP1506 | Mav_2924c | MaaPPE23 | MiPPE23 | IV | 97.8 | 98.9 | 72.7 | 98.3 | 71.6 | 72.0 |
| MACPPE24 | PPE25 | MAP1505 | Mav_2925c | MaaPPE24 | MiPPE24 | IV | 93.9 | 97.6 | 74.7 | 93.4 | 74.3 | 74.6 |
| MACPPE24 | PPE26 | MAP1506 | Mav_2926c | MaaPPE23 | MiPPE23 | IV | 98.9 | 98.9 | 72.7 | 100.0 | 72.1 | 72.0 |
| MACPPE24 | PPE25 | MAP1505 | Mav_2928c | MaaPPE24 | MiPPE24 | IV | 97.6 | 97.6 | 74.7 | 99.8 | 74.6 | 74.6 |
| MACPPE27 | A | MAP1155 | Mav_3353c | MaaPPE27 | IV | 98.2 | 98.2 | 99.4 | ||||
| MACPPE28 | A | MAP1153 | Mav_3355c | MaaPPE28 | MiPPE28 | IV | 98.8 | 98.7 | 76.9 | 99.7 | 76.6 | 76.5 |
| MACPPE29 | A | MAP1152 | Mav_3356c | MaaPPE29 | MiPPE29 | IV | 99.1 | 99.1 | 70.0 | 100.0 | 70.2 | 70.2 |
| MACPPE30 | A | MAP1144c | MaaPPE30 | MiPPE30 | II | 99.1 | 76.1 | 75.7 | ||||
| MACPPE31 | A | MAP2927 | Mav_3715 | MaaPPE31 | MiPPE31 | IV | 98.3 | 98.6 | 68.6 | 98.6 | 68.6 | 68.3 |
| MACPPE32 | PPE50 | MAP3184 | Mav_4014 | MaaPPE32 | MiPPE32 | IV | 98.9 | 99.5 | 81.9 | 99.4 | 82.0 | 82.1 |
| MACPPE33 | PPE51 | MAP3185 | Mav_4015 | MaaPPE33 | MiPPE33 | IV | 98.7 | 98.6 | 76.6 | 99.0 | 76.7 | 76.9 |
| MACPPE34 | A | MAP3419c | Mav_4273c | MaaPPE34 | MiPPE34 | IV | 99.5 | 99.3 | 77.8 | 99.5 | 77.9 | 78.0 |
| MACPPE35 | A | MAP3420c | Mav_4274c | MaaPPE35 | MiPPE35 | IV | 99.5 | 99.3 | 83.8 | 99.5 | 83.8 | 83.6 |
| MACPPE36 | A | MAP3490 | Mav_4349 | MaaPPE36 | MiPPE36 | II | 99.1 | 99.3 | 82.7 | 98.9 | 81.5 | 81.7 |
| MACPPE37 | PPE10 | MAP3939c | Mav_4704 | MaaPPE37 | MiPPE37 | V | 99.7 | 99.5 | 89.6 | 99.5 | 89.5 | 89.8 |
| MACPPE38 | PPE4 | MAP3782 | Mav_4867c | MaaPPE38 | MiPPE38 | II | 98.7 | 98.6 | 84.3 | 99.1 | 85.4 | 84.8 |
| MACPPE39 | PPE2 | Mav_4872c | MaaPPE39 | II | 99.6 | |||||||
| MACPPE40 | A | MAP3765 | Mav_4879c | MaaPPE40 | MiPPE40 | II | 74.9 | 74.4 | 77.1 | 98.7 | 83.3 | 82.9 |
| MACPPE41 | PPE3 | MAP3725 | II | |||||||||
| MACPPE42 | A | MAP3737 | II | |||||||||
| MACPPE43 | PPE65 | MiPPE43 | IV | |||||||||
| MACPPE44 | A | MiPPE44 | IV | |||||||||
| MACPPE45 | A | MiPPE45 | IV | |||||||||
| MACPPE46 | PPE32 | MiPPE46 | IV | |||||||||
| MACPPE47 | A | MiPPE47 | IV | |||||||||
| MACPPE48 | PPE31 | MiPPE48 | IV | |||||||||
| MACPPE49 | A | MAP1152 | Mav_3356c | MiPPE49 | IV | 99.1 | 99.1 | 70.5 | 100.0 | 70.7 | 70.7 | |
| Mean | 98.1 | 98.2 | 79.6 | 98.6 | 79.6 | 80.0 | ||||||
| SD | 4.1 | 4.0 | 5.5 | 4.4 | 5.6 | 6.1 | ||||||
a
A, absent; *, truncated gene.