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CHIP overexpression regulates the contractile phenotype in rat aortic rings. Shown are concentration-response curves for phenylephrine (A), acetylcholine (B), and SNP (C) in rat aortic rings transduced for 2 days with Ad-GFP (n = 4) or Ad-CHIP (n = 4). Means ± SEM from four rings per group are shown. *, P < 0.01 versus Ad-GFP. (D) Schematic model depicting the role of CHIP in SMC phenotype modulation via promoting myocardin degradation.
