Figure 4.

Temporal evolution of SOAEs following aminoglycoside injection. (A) Intraperitoneal administration of 500 mg⋅kg⁻¹ kanamycin sulfate suppressed emissions below 3.0 kHz and facilitated those at higher frequencies. Recovery was essentially complete less than 2 hr after drug administration. (B) Injection of the same dose of gentamicin sulfate into a different animal suppressed emissions below 3.0 kHz and facilitated of those at higher frequencies. The augmentation of high-frequency emissions progressed from a broad peak to a cluster of discrete peaks that grew in size.