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. 2009 Feb 25;83(9):4605–4615. doi: 10.1128/JVI.02017-08

FIG. 6.

FIG. 6.

Phylogenetic clustering as a consequence of artificial imposition of HLA-B*5703 mutations on HLA-B*5703-negative Gag sequences. ML phylogenetic trees constructed from 100 Gag sequences (selected at random from a pool of HLA-B*5703-negative individuals). The same 100 sequences are represented in each tree, and the same 20 are marked with arrows. (A) Twenty taxa were selected at random (marked with arrows). In this panel, no footprint mutations have been added. (B) The same sequences after the addition of three HLA-B*5703 footprint mutations to the arrowed sequences. (C) The same sequences after the addition of five footprint mutations. Progressive phylogenetic clustering among sequences bearing the HLA-B*5703 footprint is evident.