TABLE 1.
Correlation between sites of HLA-mediated immune selection pressurea and sites of interclade variability in clades A1, A2, AE, B, and Cb
| Protein(s) | HLA-A | HLA-B | HLA-C |
|---|---|---|---|
| Gag | |||
| p17 | 0.15 | 8.68 × 10−3 | 1 |
| p24 | 4.27 × 10−3 | 5.04 × 10−10 | 0.62 |
| p15 | 1 | 0.47 | 1 |
| Pol | |||
| Protease | 0.076 | 1.92 × 10−3 | 0.19 |
| RT | 2.22 × 10−3 | 2.21 × 10−6 | 2.63 × 10−7 |
| Integrase | 0.14 | 1.19 × 10−3 | 1 |
| Nef | 0.032 | 0.018 | 0.24 |
| Gag + Pol + Nef | 4.13 × 10−7 | 9.77 × 10−19 | 1.34 × 10−5 |
a
q, <0.2.
b
Fisher's exact test was used to determine statistically significant associations (P < 0.001, corrected for multiple comparisons by the Bonferroni method), which are in bold and underlined.