TABLE 1.
Baseline characteristics for 29 PML cases
| Characteristicsa | Summary statisticb
|
Pc | ||
|---|---|---|---|---|
| All patients (n = 29) | Survivors (n = 18) | Nonsurvivors (n = 11) | ||
| Age (yr) | 39 (36, 45) | 37 (34, 44) | 42 (39, 45) | 0.13 |
| Female gender | 5 (17) | 2 (11) | 3 (27) | 0.34 |
| PML diagnosis | ||||
| Definitive | 4 (14) | 2 (11) | 2 (18) | 0.09 |
| Laboratory confirmed | 10 (34) | 4 (22) | 6 (55) | |
| Possible | 15 (52) | 12 (67) | 3 (27) | |
| Yr since first positive HIV test | 8.20 (2.72, 11.34) | 7.10 (0.51, 9.14) | 10.81 (8.30,13.19) | 0.03 |
| CD4 cell count (cells/μl) | 102 (35, 152) | 119 (82, 192) | 35 (18, 107) | 0.02 |
| CD8 cell count (cells/μl) | 700 (455, 1137) | 698 (546, 1030) | 700 (425, 1168) | 0.74 |
| HIV viral load (log10 copies/ml) | 4.18 (2.62, 5.28) | 3.88 (2.62, 4.88) | 4.98 (2.79, 5.41) | 0.22 |
| Prior AIDS-defining conditions | 12 (41) | 9 (50) | 3 (27) | 0.27 |
| cART status at PML diagnosis | ||||
| cART naïve | 10 (34) | 7 (39) | 3 (27) | 0.45 |
| cART treated | 10 (34) | 7 (39) | 3 (27) | |
| cART interrupted | 9 (31) | 4 (22) | 5 (45) | |
| cART (re)initiated within 3 mo of PML diagnosis | ||||
| In cART-naïve patients | 7/10 (70) | 6/7 (86) | 1/3 (33) | 0.10 |
| In cART-pretreated patients | 4/9 (44) | 3/4 (75) | 1/5 (20) | |
a
Time-dependent covariates evaluated at the time of PML diagnosis.
b
Median (IQR) for continuous variables; n (%) for categorical variables.
c
Survivors versus nonsurvivors; based on Wilcoxon test for continuous variables and Fisher's exact test for categorical variables.