TABLE 1.

Significantly different genes in cross-comparisons in the microarray analyses

Comparison and gene at 24 hpia	Avg fold regulation ± SD	No. of significant features/total no. of features	Kineticsb	Protein function
p53−/− cells vs THF
UL30	−2.37 ± 0.09	2/3	N/A	N/A
UL48	−2.93 ± 0.67	3/4	L	Tegument protein
UL54	−2.82 ± 0.34	3/3	E	DNA polymerase subunit
UL63	−5.79 ± 0.83	3/3	E	N/A
UL65	−7.11 ± 0.47	3/3	L	N/A
UL68	−2.26 ± 0.41	2/3	L	N/A
UL69	−2.36 ± 0.39	3/3	E-L	Transcriptional regulator
UL75	−3.31 ± 0.73	2/3	E-L	Envelope glycoprotein
UL84	−2.48 ± 0.19	3/4	E-L	Transcriptional regulator
UL100	−2.32 ± 0.28	3/3	E-L	Envelope glycoprotein
UL106	−2.07 ± 0.09	2/3	L	N/A
UL109	−2.45 ± 0.25	3/4	IE-L	N/A
UL110	−3.46 ± 0.43	3/3	L	N/A
UL111	−2.30 ± 0.17	2/3	IE-L	N/A
UL122	−2.27 ± 0.23	4/4	IE	Transcriptional regulator IE2
IRL4	−2.68 ± 0.09	4/6	E	N/A
IRS1	−2.32 ± 0.15	2/4	IE	Transcriptional regulator TRS1
RL5A	−2.60 ± 0.18	6/6	N/A	Probably a glycoprotein
TRS1	−3.12 ± 0.21	4/4	IE	Transcriptional regulator TRS1
p53−/− cells vs HFF
UL14	2.09 ± 0.15	3/5	L	N/A
UL16	2.16 ± 0.17	3/3	E	Glycoprotein, immunoevasin
UL30	−2.12 ± 0.07	2/3	N/A	N/A
UL54	−2.25 ± 0.15	3/3	E	DNA polymerase subunit
UL63	−5.10 ± 1.09	3/3	E	N/A
UL65	−6.86 ± 0.72	3/3	L	N/A
UL69	−2.12 ± 0.19	3/3	E-L	Transcriptional regulator
UL75	−2.71 ± 0.60	2/3	E-L	Envelope glycoprotein
UL110	−2.17 ± 0.11	3/3	L	N/A
UL122	−2.08 ± 0.10	4/4	E	Transcriptional regulator IE2
US2	4.26 ± 0.35	4/4	E	Glycoprotein
IRL4	−2.37 ± 0.14	4/6	E	N/A
IRS1	−2.32 ± 0.15	2/4	IE	Transcriptional regulator TRS1
TRS1	−2.13 ± 0.12	4/4	IE	Transcriptional regulator TRS1
HFF vs THF, US2	2.43 ± 0.34	4/4	E	Glycoprotein

^aGenes that are shared between HFF and THF cells in comparisons with p53^−/− cells are shown in boldface. No significant differences in gene expression between different cell types were found at 12 hpi.

^bExpression kinetics of each gene as determined in reference 8. N/A, information not available.