FIG. 4.

Dimer interface of NS5A(33-202) as seen looking through monomer B (yellow ribbon) onto monomer A (blue surface). Residues of monomer A in contact with monomer B are colored either magenta or green. Magenta signifies amino acid conservation above 95% based on 35 sequences spanning genotypes 1 to 6 from the Los Alamos database (20). Water molecules at the interface are shown as red spheres, and the trapped glycerol is an orange stick model. Intermolecular main-chain-main-chain H bonds formed between Gly 96 N and Ala 92 O are colored and labeled separately.