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. 2009 Feb 18;83(9):4051–4059. doi: 10.1128/JVI.02645-08

FIG. 3.

FIG. 3.

(A) The subtype B WT competed with the 41L215Y double mutant at a ratio of 20:80, respectively. (B) The subtype C WT competed with the 41L215Y double mutant at the same initial ratio as in panel A. (C) The subtype B competition with the 70R215F mutant at a ratio of 40% WT to 60% mutant. (D) The 70R215F competition in subtype C at a ratio of 40% WT to 60% mutant. (E) Summary of all double-mutant competitions, with the 215Y and 215F single mutants included as a reference. The 41L215Y mutant is in the TAM-1 pathway. The 70R215F mutant is in the TAM-2 pathway, and the 70R215Y mutant is in the mixed TAM pathway. The bars are the means of five replicates, and the error bars are 1 standard deviation. All bars marked with asterisks have a P value of less than 0.01 according the Mann-Whitney rank sum test compared to the subtype-specific WT. The bars marked with a plus have a P value of less than 0.01 according to the Mann-Whitney rank sum test compared to each other.