TABLE 1.
Sample summarya
| Subject | Sex | Age (mos) | Additional diagnosis | Outcome | No. of subclones analyzed by Sanger sequencing | No. of sequences obtained by 454 pyrosequencing | Eukaryotic virus(es) detected |
|---|---|---|---|---|---|---|---|
| AFP patients | |||||||
| 1449 | M | 96 | Unknown | Residual weakness | 49 | 14,713 | Cosavirus, nodavirus-like virus |
| 6278 | F | 30 | Hemiplegia | Residual weakness | 130 | 8,924 | None |
| 6341 | M | 4 | Hemiplegia | Full recovery | 57 | 5,456 | None |
| 6344 | M | 60 | Unknown | Full recovery | 102 | 23,477 | Cosavirus, dicistrovirus-like virus |
| 5727 | F | 24 | Other | Residual weakness | 130 | 3,715 | Tobacco green mosaic virus |
| 6178 | M | 36 | Hemiplegia | Death | 181 | 20,052 | Cosavirus, dicistrovirus-like virus, anellovirus (TTV), HEV-B, HEV-C |
| 6187 | M | 60 | Encephalitis/meningitis | Full recovery | 240 | 17,705 | Aichi virus, adenovirus |
| 5192 | M | 36 | Unknown | Full recovery | 59 | 4,019 | Adenovirus, Aichi virus, cosavirus |
| 5550 | M | 1 | NPE myelitis | Death | 52 | 8,276 | Adenovirus, cosavirus, HEV-B, HEV-C, cucumber mosaic virus, rhinovirus |
| 6572 | F | 48 | Unknown | Unknown | 129 | 25,516 | Cosavirus, HEV-C, HEV-B, human cardiovirus, plant virus |
| 1988 | M | 13 | Other | Full recovery | 45 | HEV-B | |
| 2111 | F | 120 | Hypokemia | Full recovery | 40 | HEV-A | |
| 2131 | M | 11 | Hypokemia | Full recovery | 36 | HEV-A, HEV-B | |
| 2178 | M | 30 | Unknown | Residual weakness | 50 | Adenovirus, HEV-C | |
| 2204 | M | 15 | Unknown | Residual weakness | 45 | HEV-A | |
| 2255 | F | 12 | Hypokemia | Full recovery | 38 | Parechovirus, picobirnavirus, pepper mottle virus | |
| 2263 | F | 24 | Hemiplegia | Residual weakness | 47 | Aichi virus, tobacco green mosaic virus | |
| 2291 | M | 122 | Other | Full recovery | 41 | Aichi virus | |
| 2295 | F | 26 | Traumatic neuritis | Full recovery | 39 | Aichi virus, picobirnavirus | |
| 2296 | M | 174 | Unknown | Death | 92 | Cosavirus, HEV-B | |
| 2299 | M | 96 | Hemiplegia | Residual weakness | 40 | HEV-A | |
| 5002 | F | 7 | Hypokemia | Full recovery | 58 | Rotavirus | |
| 5003 | M | 7 | Traumatic neuritis | Full recovery | 91 | Anellovirus (TTV), HEV-B, human cardiovirus, rotavirus | |
| 5004 | M | 72 | Unknown | Residual weakness | 43 | HEV-A | |
| 5005 | M | 96 | Other | Full recovery | 44 | HEV-A | |
| 5008 | M | 36 | Unknown | Full recovery | 35 | HEV-A | |
| 5034 | M | 84 | Unknown | Residual weakness | 110 | Cosavirus, HEV-C | |
| 5048 | M | 42 | Unknown | Unknown | 62 | None | |
| 5152 | M | 156 | Other | Full recovery | 41 | Human cardiovirus, unclassified Partitiviridae viruses | |
| 5222 | F | 60 | Unknown | Unknown | 88 | None | |
| 5510 | M | 36 | Unknown | Full recovery | 98 | Bocavirus, dicistrovirus-like virus, HEV-C | |
| 5551 | M | 8 | Encephalitis/meningitis | Residual weakness | 133 | Rotavirus | |
| 6197 | F | 23 | Encephalitis/meningitis | Death | 183 | HEV-B, HEV-C | |
| 6377 | M | 84 | Traumatic neuritis | Full recovery | 44 | None | |
| 6584 | F | 72 | Unknown | Unknown | 85 | None | |
| Contacts | |||||||
| 5006C | F | 24 | NA | NA | 83 | Aichi virus, cosavirus, circovirus-like virus, HEV-C | |
| 5045C | M | 25 | NA | NA | 86 | HEV-C, parechovirus | |
| 5044C | F | 24 | NA | NA | 70 | HEV-C, anellovirus (TTV) | |
| 5046C | F | 6 | NA | NA | 91 | Cosavirus, HEV-B, HEV-C, rhinovirus, anellovirus (TTV) | |
| 5047C | M | 11 | NA | NA | 47 | HEV-B, HEV-C | |
| 5048C | M | 48 | NA | NA | 62 | Cosavirus, HEV-A, HEV-B, HEV-C |
a
M, male; F, female; NA, not applicable; NPE, nonpolio enterovirus.