Table 2.
Univariate Association of Prognostic Factors and Transplantation Outcomes
| Grade 3 or 4 Toxicity by day 100 |
Duration of Transplant Hospital Stay | aGVHD | Non-Relapse Mortality | Overall Survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Infection | Hepatic | |||||||||||
| Factor | ||||||||||||
| HR | P | HR | P | HR | P | HR | P | HR | P | HR | P | |
| Age ≥ 50 years | 0.84 | 0.52 | 1.1 | 0.81 | 1.3 | 0.19 | 0.98 | 0.95 | 2.0 | 0.06 | 1.8 | 0.02 |
| Active Disease | 1.2 | 0.53 | 1.5 | 0.30 | 1.9 | 0.001 | 0.70 | 0.33 | 2.2 | 0.03 | 3.1 | <0.001 |
| HCT-CI ≥ 3 | 0.97 | 0.92 | 1.0 | 0.93 | 1.4 | 0.11 | 0.65 | 0.27 | 1.4 | 0.37 | 2.0 | 0.004 |
| PS ≥ 1 | 1.0 | 0.91 | 2.0 | 0.05 | 1.4 | 0.10 | 2.4 | 0.02 | 3.6 | <0.001 | 2.5 | <0.001 |
| CRP, above median | 1.8 | 0.09 | 3.1 | 0.01 | 2.0 | 0.005 | 4.1 | 0.003 | 3.1 | 0.01 | 2.0 | 0.02 |
| IL-6, above median | 1.5 | 0.24 | 1.9 | 0.14 | 1.3 | 0.27 | 1.3 | 0.75 | 1.7 | 0.22 | 1.3 | 0.41 |
aGVHD- Acute graft-versus-host disease
HCT-CI- Hematopoietic Cell Transplantation-Comorbidity Index
PS- Eastern Cooperative Oncology Group Performance Score
CRP- C-reactive protein
IL-6- Interleukin-6
HR - Hazard ratio