. Author manuscript; available in PMC: 2009 Dec 1.

Published in final edited form as: Bioorg Med Chem. 2008 Oct 11;16(23):10061–10074. doi: 10.1016/j.bmc.2008.10.013

Table 5.

Comparison of K_i,s Values Between Insect and Mammalian PHM

Compound

K_i,s (μM) vs. B. germanica PHM

\frac{Rat K_{i, s}}{Insect K_{i, s}}

S-(3-Phenylthiopropionyl)thioglycolic acid (62)

0.87 ± 0.11

S-(2-Phenylthioacetyl)thioglycolic acid (60)

3.6 ± 0.6

2.1

S-(Thiobenzoyl)thioglycolic acid (64)

92 ± 10

1.9

S-(Phenylthiocarbamoyl)thioglycolic acid (61)

5.4 ± 0.3

1.6

S-(Phenylthiocarbamoyl)-3-mercaptopropionic acid (56)

5.5 ± 0.8

0.47

S-(4-Methylthiobenzoyl)thioglycolic acid (57)

14 ± 1

0.25

S-Phenylmercaptoacetic Acid (72)

56 ± 6

6.9