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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Nat Methods. 2009 Mar 22;6(4):283–289. doi: 10.1038/nmeth.1313

Fig. 3. Mean nucleotide-level accessibility parallels protein:DNA interactions.

Fig. 3

(a) Structure of Mcm1 (green) bound to a single DNA recognition site16 (adjacent Matα2 was removed for clarity). Colored DNA bases correspond to positions within the footprint-derived Mcm1 motif (below), and red DNA backbone coloration reflects the extent of observed DNase I cleavage across 88 Mcm1 sites (red trace in subpanel). Mean nucleotide-level conservation by PhastCons11 is shown in parallel (blue trace in subpanel; P < 10-5). (b) Structure of the human homolog of CBF117 is shown relative to the mean nucleotide level cleavage and conservation (P < 10-3) across 243 Cbf1 sites.