. Author manuscript; available in PMC: 2009 May 1.

Published in final edited form as: J Membr Biol. 2008 Jun 25;223(1):13–26. doi: 10.1007/s00232-008-9107-7

Table 2.

Summary of results for planar lipid bilayer nAChR ion channel function assays.

Detergent	Average number of processed events per- bilayer (N)	Channel current (mean ± SD) pA	Open channel time (mean ± SD) ms
Cholate	214	−(2.48 ± 0.03)	(3.0 ± 0.1)
CHAPS	262	−(2.69 ± 0.04)	(3.51 ± 0.04)
FC-12	285	−(2.48 ± 0.02)	(2.52 ± 0.07)
Anapoe-C₁₂E₉	274	−(1.77 ± 0.02)	(2.40 ± 0.03)
BigCHAP	235	−(1.76 ± 0.05)	(2.05 ± 0.05)
Cymal-6	N/A	N/A	N/A
DDM	N/A	N/A	N/A
LDAO	N/A	N/A	N/A
OG	N/A	N/A	N/A

-N/A means that Carb.-induced activity was not observed. For functional detergents, an average of three (3) bilayer experiments with durations of ~30 min. were performed. For detergents that did not display Carb.-induced activity, an average of six (6) bilayer experiments with durations of ~45 min. were performed. Histograms from which mean ion channel current and mean open channel time electrophysiological parameter values were obtained are shown as supplementary materials.