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. Author manuscript; available in PMC: 2009 Apr 13.
Published in final edited form as: J Am Chem Soc. 2008 Jun 25;130(29):9200–9201. doi: 10.1021/ja802353j

Scheme 1. Synthesis of C1-Substituted DPD Analoguesa.

Scheme 1

a Conditions: (a) LDA, TMSCHN2, -78 °C, 6 h, 71%; (b) n-BuLi, R-I, -78 °C to room temp, 12 h, 40-75%; (c) RuO2, NaIO4, MeCN, CCl4, H2O, 15 min. (see Table 1 for yields); (d) pH 1.5, 99%.