Table 2.
Summary of QS Modulation by C1-Alkylated DPD Analogues
| compound | IC50 in S. typhimurium assay (μM)a | fold-activation in V. harveyi assayb |
|---|---|---|
| ethyl-DPD (5b) | > 50 | 6.30 ± 0.72 |
| propyl-DPD (5c) | 5.30 ± 0.43 | 7.69 ± 0.30 |
| butyl-DPD (5d) | 5.04 ± 0.61 | 6.05 ± 0.93 |
| hexyl-DPD (5e) | 24.9 ± 5.4 | 2.74 ± 0.24 |
| phenyl-DPD (5f) | > 50 | 1.81 ± 0.12 |
| azidobutyl-DPD (5g) | 20.3 ± 1.3 | 7.44 ± 0.77 |
a
Assay performed in the presence of 50 μM DPD and varying concentrations of test compound.
b
Assay performed in the presence of 1 μM DPD and 25 μM compound. Luminescence was measured after 8 h.