Table 4.
CYP19A1 SNPs and risk of endometrial cancer stratified by body mass index (kg/m2)
| SNP | BMI <25 kg/m2 |
25 ≤ BMI <30 kg/m2 |
BMI ≥30 kg/m2 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR* (95% CI) | Cases | Controls | OR* (95% CI) | Cases | Controls | OR* (95% CI) | |
| rs749292 | |||||||||
| All women | |||||||||
| n | 1,697 | 3,954 | 1,309 | 2,076 | 1,278 | 1,125 | |||
| GG | 467 | 1,225 | 1.00 | 342 | 679 | 1.00 | 326 | 349 | 1.00 |
| AG | 866 | 1,974 | 1.10 (0.97-1.25) | 664 | 994 | 1.27 (1.07-1.51) | 648 | 559 | 1.23 (1.00-1.50) |
| AA | 364 | 755 | 1.17 (1.00-1.37) | 303 | 403 | 1.37 (1.11-1.69) | 304 | 217 | 1.49 (1.16-1.91) |
| Per allele | 1.08 (1.00-1.17) | 1.18 (1.06-1.31) | 1.22 (1.08-1.38) | ||||||
| Women age <55 y | |||||||||
| n | 549 | 1,115 | 344 | 439 | 327 | 268 | |||
| GG | 157 | 318 | 1.00 | 98 | 135 | 1.00 | 85 | 83 | 1.00 |
| AG | 282 | 574 | 0.93 (0.74-1.17) | 161 | 219 | 0.92 (0.64-1.33) | 161 | 136 | 1.08 (0.70-1.66) |
| AA | 110 | 223 | 0.97 (0.73-1.29) | 85 | 85 | 1.18 (0.76-1.82) | 81 | 49 | 1.55 (0.91-2.64) |
| Per allele | 0.98 (0.85-1.13) | 1.07 (0.86-1.34) | 1.23 (0.95-1.60) | ||||||
| Women age ≥55 y | |||||||||
| n | 1,148 | 2,839 | 965 | 1,637 | 951 | 857 | |||
| GG | 310 | 907 | 1.00 | 244 | 544 | 1.00 | 241 | 266 | 1.00 |
| AG | 584 | 1,400 | 1.18 (1.01-1.38) | 503 | 775 | 1.40 (1.15-1.71) | 487 | 423 | 1.26 (1.00-1.59) |
| AA | 254 | 532 | 1.26 (1.05-1.53) | 218 | 318 | 1.43 (1.13-1.82) | 223 | 168 | 1.47 (1.10-1.95) |
| Per allele | 1.13 (1.03-1.24) | 1.21 (1.08-1.36) | 1.21 (1.05-1.40) | ||||||
| rs727479 | |||||||||
| All women | |||||||||
| n | 1,688 | 3,905 | 1,296 | 2,067 | 1,277 | 1,127 | |||
| CC | 189 | 441 | 1.00 | 118 | 217 | 1.00 | 104 | 133 | 1.00 |
| AC | 720 | 1,688 | 0.91 (0.76-1.09) | 535 | 899 | 1.05 (0.81-1.37) | 541 | 491 | 1.41 (1.04, 1.91) |
| AA | 779 | 1,776 | 0.95 (0.80-1.14) | 643 | 951 | 1.14 (0.88-1.48) | 632 | 503 | 1.63 (1.21, 2.21) |
| Per allele | 1.00 (0.92-1.09) | 1.07 (0.96-1.20) | 1.23 (1.08, 1.41) | ||||||
| Women age <55y | |||||||||
| n | 541 | 1,102 | 344 | 436 | 324 | 268 | |||
| CC | 46 | 113 | 1.00 | 40 | 42 | 1.00 | 32 | 32 | 1.00 |
| AC | 235 | 463 | 1.03 (0.73-1.45) | 127 | 182 | 0.56 (0.33-0.97) | 134 | 109 | 1.21 (0.65-2.26) |
| AA | 260 | 526 | 1.02 (0.72-1.44) | 177 | 212 | 0.66 (0.38-1.13) | 158 | 127 | 1.31 (0.70-2.44) |
| Per allele | 1.00 (0.86-1.17) | 0.93 (0.73-1.17) | 1.12 (0.85-1.48) | ||||||
| Women age ≥55 y | |||||||||
| n | 1,147 | 2,803 | 952 | 1,631 | 953 | 859 | |||
| CC | 143 | 328 | 1.00 | 78 | 175 | 1.00 | 72 | 101 | 1.00 |
| AC | 485 | 1,225 | 0.86 (0.70-1.07) | 408 | 717 | 1.25 (0.92-1.70) | 407 | 382 | 1.47 (1.03-2.09) |
| AA | 519 | 1,250 | 0.93 (0.75-1.15) | 466 | 739 | 1.34 (0.99-1.82) | 474 | 376 | 1.76 (1.24-2.51) |
| Per allele | 1.00 (0.90-1.10) | 1.13 (0.99-1.28) | 1.28 (1.10-1.49) | ||||||
*
The ORs and 95% CI were estimated using unconditional logistic regression adjusting for age, study, and race/ethnicity when appropriate.