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. Author manuscript; available in PMC: 2009 Apr 13.
Published in final edited form as: Anesth Analg. 2008 Sep;107(3):868–874. doi: 10.1213/ane.0b013e31817ee500

Fig 2.

Fig 2

Current tracings show the responses to 5 micromolar sodium dodecyl sulfate (SDS) on wild type α1β2γ2s GABAA, α1 Glycine, or NMDA NR1 /NR2A receptors, or mutant receptors α1(S270I)β2γ2s GABAA, α1 (S267I) Glycine, or NMDA NR1 (F639A) / NR2A with point mutations that attenuated the response to isoflurane and ethanol, in Xenopus oocytes. Modulatory effects were reversible in all cases. Equi-effective concentrations of agonist were use on wild type and mutant receptors. The first tracing of each group shows the response to agonist prior to application of SDS. The second tracing shows the response to SDS and agonist. The third tracing shows the response to agonist after washout of SDS.