Fig 4.

α₁ Glycine receptors expressed in Xenopus oocytes were significantly potentiated by isoflurane, ethanol, and six surfactants and inhibited by one (SDS) (all effects are significantly different from zero, P<0.05). Summary bar graphs show the mean glycine-induced responses, at EC₅ agonist concentrations, from multiple oocytes expressing α₁ glycine receptors in the presence of study compounds. Means ± SE (N = 4–7) are displayed. SDS = sodium dodecyl sulfate, SOS = sodium n-octyl sulfate, OTABR = (1-octyl)trimethylammonium bromide, DTACL = (1dodecyl) trimethylammonium chloride, DAPS = 3-(dodecyldimethylammonio)propanesulfonate. C12 = 12 carbon tail, C8 = 8 carbon tail for the surfactants. Anionic, cationic, zwitterionic, and uncharged refer to head group charges for the surfactants.