NR1 / NR2A N-methyl-D-Aspartate receptors expressed in Xenopus oocytes were inhibited by isoflurane, ethanol, and six surfactants and potentiated by DAPS (P<0.05). Bar graphs show the mean response induced by glutamate (EC50) and a saturating concentration of glycine. Means ± SE (N = 4–7) are displayed. SDS = sodium dodecyl sulfate, SOS = sodium n-octyl sulfate, OTABR = (1-octyl)trimethylammonium bromide, DTACL = (1dodecyl) trimethylammonium chloride, DAPS = 3-(dodecyldimethylammonio)propanesulfonate. C12 = 12 carbon tail, C8 = 8 carbon tail for the surfactants. Anionic, cationic, zwitterionic, and uncharged refer to head group charges for the surfactants.