Table 1.
Transcripts changed in MDSCs from ILT2 mice compared with MDSCs from C57BL/6 control micea
| Transcripts downregulated | Transcripts upregulated | ||||||
|---|---|---|---|---|---|---|---|
| Cytokines, cytokine receptors, growth factors, growth factor receptors | |||||||
| Gene name | Gene Symbol | Fold change | Gene name | Gene symbol | Fold change | ||
| Interleukin 6 signal transducer | IL6st | −10.88 | (−2.64)b | Interleukin-4 | IL4 | 5.68 | (1.19) |
| Tumor necrosis factor receptor 1β | TNFRII | −5.22 | (−3.53) | Interleukin-13 | IL13 | 4.58 | (2.63) |
| Interleukin 5 receptor α | IL5Rα | −4.39 | (−2.25) | Interleukin-1β | IL1β | 3.02 | (1.71) |
| Transforming growth factor, beta 1 | TGFβ1 | −4.12 | (−2.58) | Interferon gamma | IFNγ | 1.86 | (−1.11)c |
| Lymphotoxin beta | LTβ | −3.52 | (−3.2) | ||||
| Interleukin 2 receptor β chain | IL2Rβ | −3.37 | (−5.39) | ||||
| Interleukin 10 receptor α | IL10Rα | −3.24 | (−3.97) | ||||
| Interleukin 6 receptor α | IL6Rα | −2.92 | (−1.95) | ||||
| Interleukin 2 receptor γ chain | IL2Rγ | −2.65 | (−1.36) | ||||
| Interleukin 16 | IL16 | −2.47 | (−4.38) | ||||
| Chemokines, chemokine receptors, other genes | |||||||
| Chemokine (C-C motif) receptor 2 | CCR2 | −10.96 | (−2.36) | Chemokine (C-C motif) ligand 8 | CCL8 | 18.97 | (10.63) |
| Chemokine (C-C motif) receptor 5 | CCR5 | −8.36 | (−1.04) | Chemokine (C-X-C motif) ligand 5 | CXCL5 | 10.03 | (2.87) |
| Chemokine (C-C motif) receptor 7 | CCR7 | −6.79 | (1.34)c | Chemokine (C-X-C motif) ligand 13 | CXCL13 | 6.85 | (1.58) |
| Complement component 3 | C3 | −4.07 | (−4.17) | Chemokine (C-C motif) ligand 19 | CCL19 | 5.16 | (1.33) |
| Burkitt lymphoma receptor 1 | BLR1 | −3.52 | (−2.35) | Chemokine (C-X-C motif) receptor 3 | CXCR3 | 3.15 | (1.17) |
| B-cell leukemia/lymphoma 6 | Bcl6 | −3.26 | (−1.99) | Chemokine (C-X-C motif) ligand 4 | CXCL4 | 2.82 | (1.69) |
| Chemokine (C-C motif) ligand 2 | CCL2 | −1.87 | (3.18)c | Chemokine (C-C motif) ligand 7 | CCL7 | 2.82 | (2.04) |
| Chemokine (C-C motif) ligand 5 | CCL5 | 2.4 | (−1.13)c | ||||
a
The average fold changes were obtained by comparison of nonactivated MDSCs isolated from splenocytes of ILT2 mice with MDSCs isolated from splenocytes of control C57BL/6 mice.
b
Fold changes in allogeneic transplant-activated MDSCs from ILT2 mice compared with allogeneic transplant-activated MDSCs from C57BL/6 mice indicated in bracket.
c
Opposite changes.